Denver Broncos vs San Francisco 49ers Odds & Lines
Best available NFL odds for Denver Broncos at San Francisco 49ers, Sun, 04 Oct 2026 20:25:00 GMT.
| Team | Moneyline | Spread |
|---|---|---|
| Denver Broncos | +125 | +3 (-120) |
| San Francisco 49ers | -135 | -2.5 (-110) |
Total (O/U): +46.5 — Over -110 / Under -110 (draftkings)
Odds shown are the best available across sportsbooks and update in real time. Get alerts on line movement and sharp money with the Bettor Alerts app.