Detroit Lions vs Buffalo Bills Odds & Lines
Best available NFL odds for Detroit Lions at Buffalo Bills, Fri, 18 Sep 2026 00:15:00 GMT.
| Team | Moneyline | Spread |
|---|---|---|
| Detroit Lions | +140 | +3 (+105) |
| Buffalo Bills | -150 | -3 (-105) |
Total (O/U): +53 — Over -114 / Under -114 (nordicbet)
Odds shown are the best available across sportsbooks and update in real time. Get alerts on line movement and sharp money with the Bettor Alerts app.